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Relationship between thyroid function and carotid artery plaque ulceration.

Utkan Sevuk1, Mehmet Veysi Bahadir2, Rojhat Altindag3

  • 1Department of Cardiovascular Surgery, Diyarbakir Gazi Yasargil Education and Research Hospital, 3. kat, Uckuyular, 21010, Diyarbakir, Turkey. utkansevuk@gmail.com.

Acta Neurologica Belgica
|February 13, 2015
PubMed
Summary

Thyroid dysfunction, including subclinical hypothyroidism and hypothyroidism, is linked to carotid artery plaque ulceration and cerebrovascular events. Thyroid function tests may help stratify risk in patients with internal carotid artery stenosis.

Keywords:
Carotid artery stenosisFT4Plaque ulcerationTSHThyroid function

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Neurology

Background:

  • Carotid artery plaque ulceration (PU) is a known risk factor for cerebrovascular events (CVE).
  • Thyroid function, even within euthyroid ranges, may influence carotid atherosclerosis.
  • The specific relationship between thyroid function and carotid PU requires further elucidation.

Purpose of the Study:

  • To investigate the association between thyroid function and the presence of PU in patients with internal carotid artery stenosis (ICS).

Main Methods:

  • Retrospective review of 250 patients with ICS and CVE, utilizing computed tomography angiography (CTA) for plaque morphology and ulceration assessment.
  • Classification of plaque morphology into fatty, mixed, or calcified.
  • Comparison of thyroid function parameters (TSH, FT4) between patients with and without PU.

Main Results:

  • Subclinical hypothyroidism (SCH) and hypothyroidism were significantly more prevalent in patients with PU.
  • Patients with PU exhibited lower free thyroxine (FT4) and higher thyroid-stimulating hormone (TSH) levels.
  • Independent predictors of PU included elevated TSH, SCH, hypothyroidism, fatty plaque, and calcified plaque.

Conclusions:

  • SCH and hypothyroidism may serve as risk factors for PU and subsequent CVE.
  • Thyroid function assessment could aid in the risk stratification of patients with ICS.