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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Relative Risk01:12

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Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Non-LTR Retrotransposons03:18

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Pathophysiology of Diabetes01:20

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Related Experiment Videos

Perinatal risk factors for future SLE: a population-based nested case-control study.

E V Arkema1, J F Simard2

  • 1Department of Medicine, Karolinska Institute, Stockholm, Sweden elizabeth.arkema@ki.se.

Lupus
|February 13, 2015
PubMed
Summary

Firstborns have lower lupus risk, while each additional birth increases it. Preterm birth elevates lupus risk in males, but high birth weight is not a factor.

Keywords:
Systemic lupus erythematosusbirth orderbirth weightgestational age

Related Experiment Videos

Area of Science:

  • Epidemiology
  • Perinatal Health
  • Autoimmune Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
  • Understanding the influence of perinatal factors on SLE risk is crucial for early identification and prevention strategies.

Purpose of the Study:

  • To examine the association between perinatal characteristics and the risk of developing systemic lupus erythematosus (SLE) in offspring.
  • To investigate potential sex-specific differences in these associations.

Main Methods:

  • A nested case-control study design was employed using Swedish population-based registers.
  • Systemic lupus erythematosus (SLE) cases were identified from the National Patient Register.
  • Data on perinatal factors were extracted from the Medical Birth Register (1973-2008) and analyzed using conditional logistic regression.

Main Results:

  • High birth weight was not identified as a risk factor for SLE.
  • Preterm birth (<37 weeks) was associated with a 2.4-fold increased odds of SLE in males.
  • Birth order showed a significant association, with firstborns having reduced SLE odds (OR=0.77) and each subsequent birth increasing odds (OR=1.12).

Conclusions:

  • Firstborn status is linked to a decreased risk of SLE.
  • Preterm birth is a significant risk factor for SLE in males, but not females.
  • The findings suggest specific perinatal factors influence SLE susceptibility, with notable sex differences.