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Systemic treatment of papular dermatitis: A retrospective study
Farah A Moustafa1, Laura F Sandoval1, Joseph L Jorizzo1
1a Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
The Journal of Dermatological Treatment
|February 13, 2015
Summary
Low-dose methotrexate, azathioprine, and mycophenolate mofetil offer effective long-term control for refractory papular dermatitis. These non-steroidal systemic therapies provide treatment options for patients unresponsive to conventional methods.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Papular dermatitis presents as a severe, itchy rash.
- It often resists standard treatments, necessitating alternative therapies.
Purpose of the Study:
- To assess the effectiveness of non-steroidal systemic treatments for persistent papular dermatitis.
- To identify options for long-term disease management.
Main Methods:
- Retrospective chart review of patients diagnosed with papular dermatitis.
- Analysis of systemic therapy use between 2002 and 2012.
Main Results:
- Methotrexate, azathioprine, and mycophenolate mofetil showed efficacy in controlling papular dermatitis.
- Low-dose weekly methotrexate (2.5-10 mg) was effective in 8/12 first-line patients.
- Azathioprine was effective for methotrexate-intolerant patients, but GI side effects were noted.
Conclusions:
- Low-dose methotrexate, azathioprine, and mycophenolate mofetil are viable long-term treatments.
- These agents offer alternatives for papular dermatitis refractory to other therapies.
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