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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Derivation of Human Embryonic Stem Cells by Immunosurgery
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Sourcing human embryos for embryonic stem cell lines: problems & perspectives.

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  • 1Trivector Embryology Support Academy, Mumbai, India.

The Indian Journal of Medical Research
|February 13, 2015
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Summary
This summary is machine-generated.

Deriving human embryonic stem cells (hESC) from IVF embryos offers applications in developmental biology and regenerative medicine. This paper explores ethical methods for procuring embryos for hESC derivation, including those with abnormal morphology.

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Area of Science:

  • Stem Cell Biology
  • Developmental Biology
  • Regenerative Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Human embryonic stem cells (hESC) derived from IVF embryos hold significant potential for understanding human development and advancing regenerative medicine.
  • Current sources of embryos for hESC derivation are typically 'spare' or 'discarded' embryos from IVF procedures.
  • Ethical considerations arise regarding embryo procurement, including potential overstimulation for egg retrieval and the fate of morphologically abnormal embryos.

Purpose of the Study:

  • To discuss novel methods for procuring embryos for embryonic stem cell line derivation.
  • To address ethical concerns associated with embryo sourcing for stem cell research.
  • To explore the potential use of stem cells derived from morphologically abnormal embryos.

Main Methods:

  • Review of current practices in embryo procurement for hESC derivation.
  • Discussion of ethical debates surrounding embryo sourcing and quality assessment.
  • Exploration of newer methods for embryo procurement that balance ethical considerations with the need for source material.

Main Results:

  • Embryo quality assessment is currently subjective, relying primarily on morphology and developmental rate.
  • Ethical questions persist regarding the stimulation of women for extra eggs and the discarding of embryos.
  • The paper proposes newer methods to ethically source embryos for hESC derivation.

Conclusions:

  • There is a need for improved, objective criteria for embryo assessment to guide decisions on discarding embryos.
  • Newer procurement methods are being explored to ethically source embryos for hESC derivation, including those with suboptimal morphology.
  • Advancing regenerative medicine requires innovative approaches to stem cell sourcing while respecting ethical boundaries.