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Related Concept Videos

Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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Routes of Drug Administration: Parenteral01:25

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
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Transdermal Drug Delivery Systems01:18

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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RISUG: an intravasal injectable male contraceptive.

N K Lohiya1, I Alam, M Hussain

  • 1Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.

The Indian Journal of Medical Research
|February 13, 2015
PubMed
Summary
This summary is machine-generated.

Reversible Inhibition of Sperm Under Guidance (RISUG) offers long-term male contraception, but its development is slow. Further research is needed to confirm reversibility and long-term safety in humans.

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Area of Science:

  • Reproductive medicine
  • Biomaterials science

Background:

  • Reversible Inhibition of Sperm Under Guidance (RISUG) has emerged as a promising long-term male contraceptive over the past two decades.
  • It offers potential for 10-15 years of sterility with reported reversibility in animal models.

Purpose of the Study:

  • To review the advances and identify knowledge gaps in the development of RISUG.
  • To clarify the formulation, mechanism of action, and clinical trial data for RISUG.

Main Methods:

  • Comprehensive literature review of published works and available resources on RISUG.
  • Analysis of RISUG formulation, mechanism of action, and clinical trial outcomes.

Main Results:

  • RISUG demonstrates potential for long-term, reversible male contraception.
  • Key information regarding its copolymer nature, precise mechanism, and long-term effects, including progeny safety, remains unclear.
  • Developmental progress has been notably slow.

Conclusions:

  • RISUG presents a unique option for male contraception, but significant data gaps hinder its widespread adoption.
  • Further research is crucial to address uncertainties surrounding its long-term efficacy, safety, and reversibility in humans.