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An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
Published on: July 22, 2011
A case of extended spectrum beta-lactamase producing Salmonella enterica serotype paratyphi A from India
Priyamvada Roy, Deepti Rawat, Sonia Malik1
1Department of Microbiology, Maulana Azad Medical College, Delhi, India.
Abstract:
Enteric fever caused by Salmonella enterica is a systemic infection with high rates of morbidity and mortality. Increasing antibiotic resistance in S. enterica has led to shift in the choice of antibiotics used against this organism from chloramphenicol and ampicillin to trimethoprim-sulfamethoxazole, fluoroquinolones, and extended-spectrum cephalosporins. Resistance to cephalosporins, due to the production of extended-spectrum beta-lactamases (ESBLs), is the cause of serious concern worldwide. So far, these enzymes have been detected in many species of the family Enterobacteriaceae including different serotypes of S. enterica. To the best of our knowledge, however, ESBL production in Salmonella Paratyphi A has not yet been reported from India. We present here a case of ESBL producing Salmonella Paratyphi A from India. This is a worrisome finding with grave clinical implications, since the dissemination of this resistance trait would further limit the therapeutic options available for the treatment of enteric fever.
Insights
A case of extended-spectrum beta-lactamase (ESBL) producing Salmonella Paratyphi A was identified in India. This finding is concerning due to limited treatment options for enteric fever.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Enteric fever, caused by Salmonella enterica, is a significant global health concern with high morbidity and mortality.
- Increasing antibiotic resistance in S. enterica necessitates shifts in treatment strategies, moving away from older drugs towards newer agents like fluoroquinolones and cephalosporins.
- The emergence of extended-spectrum beta-lactamases (ESBLs) in Enterobacteriaceae, including Salmonella serotypes, poses a serious global threat.
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