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Related Experiment Videos

Chronic cough: eosinophilic bronchitis without asthma.

P G Gibson1, J Dolovich, J Denburg

  • 1Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Lancet (London, England)
|June 17, 1989
PubMed
Summary
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Chronic cough and asthma show airway inflammation with eosinophils and metachromatic cells in sputum. Chronic bronchitis is dominated by macrophages, suggesting revised obstructive airways disease definitions may be needed.

Area of Science:

  • Pulmonology
  • Cellular Biology

Background:

  • Chronic cough and chronic bronchitis are common respiratory conditions.
  • Asthma exacerbations involve significant airway inflammation.

Purpose of the Study:

  • To compare sputum cell counts in non-smokers with corticosteroid-responsive chronic cough, smokers with chronic bronchitis, and non-smokers with asthma.
  • To investigate the relationship between airway inflammation markers and airway responsiveness.

Main Methods:

  • Sputum cell differential counts were performed.
  • Subjects included non-smokers with chronic cough, smokers with chronic bronchitis, and asthmatic patients.
  • Lung function tests and methacholine airway responsiveness were assessed.

Main Results:

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  • Sputum from asthmatic patients and those with chronic cough showed eosinophils and metachromatic cells.
  • Macrophages were the predominant cell type in chronic bronchitis sputum.
  • Airway inflammation was not consistently associated with increased airway responsiveness.

Conclusions:

  • Airway inflammation characterized by eosinophils and metachromatic cells can occur without increased airway responsiveness.
  • Current definitions of obstructive airways disease may require revision based on these findings.