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Updated: Apr 17, 2026
Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
Published on: July 2, 2016
Ebola virus disease in mice with transplanted human hematopoietic stem cells
Anja Lüdtke1, Lisa Oestereich2, Paula Ruibal1
1Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany German Centre for Infection Research (DZIF), Partner Site Hamburg, Hamburg, Germany.
Abstract:
The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality. Our study provides a small-animal model with human components for the development of EVD therapies.
