Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Signaling in Plants01:25

Cell Signaling in Plants

7.1K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
7.1K
Allosteric Regulation01:08

Allosteric Regulation

64.9K
Allosteric regulation of enzymes occurs when the binding of an effector molecule to a site that is different from the active site causes a change in the enzymatic activity. This alternate site is called an allosteric site, and an enzyme can contain more than one of these sites. Allosteric regulation can either be positive or negative, resulting in an increase or decrease in enzyme activity. Most enzymes that display allosteric regulation are metabolic enzymes involved in the degradation or...
64.9K
Allosteric Regulation01:08

Allosteric Regulation

16.5K
16.5K
The Two-State Receptor Model01:29

The Two-State Receptor Model

3.6K
The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with...
3.6K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

6.5K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
6.5K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

6.0K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Root growth and branching are enabled by brassinosteroid-regulated growth anisotropy and carbon allocation.

Nature communications·2025
Same author

Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells.

Cell·2025
Same author

Focus on root development.

Plant physiology·2024
Same author

The whole and its parts: cell-specific functions of brassinosteroids.

Trends in plant science·2024
Same author

Brassinosteroids in Focus.

Plant & cell physiology·2024
Same author

Jasmonate signaling modulates root growth by suppressing iron accumulation during ammonium stress.

Plant physiology·2024
Same journal

A sugar flow model predicts cell dynamics, weight and quality of tomato at varying sink-source ratios and temperatures.

Journal of experimental botany·2026
Same journal

Crosstalks between plant proteostasis and chromatin remodeling machineries.

Journal of experimental botany·2026
Same journal

Novel Imaging Approaches for Visualising Root-Mycorrhizal Fungal Interactions.

Journal of experimental botany·2026
Same journal

The ga3ox1b mutation reveals the crosstalk between gibberellin and other phytohormones in controlling the growth and development of female flowers in Cucurbita pepo.

Journal of experimental botany·2026
Same journal

Increased grain weight conferred by GW2 mutations in wheat does not translate into yield gains in multi-year field trials of near-isogenic lines.

Journal of experimental botany·2026
Same journal

Serendipita indica promotes rice phosphorus uptake by plasma membrane H+-ATPase OsA1-stimulated root hair growth.

Journal of experimental botany·2026
See all related articles

Related Experiment Video

Updated: Apr 17, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

13.3K

Growth control: brassinosteroid activity gets context.

Amar Pal Singh1, Sigal Savaldi-Goldstein2

  • 1Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.

Journal of Experimental Botany
|February 13, 2015
PubMed
Summary
This summary is machine-generated.

Brassinosteroids regulate plant growth complexly, acting as both promoters and inhibitors. This review examines how brassinosteroid signaling integrates with other pathways to control plant development and organ growth.

Keywords:
Brassinosteroid signallinggrowth coordinationmeristem sizephytohormoneroot growthshoot growth.

More Related Videos

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

17.0K
Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster
12:10

Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster

Published on: April 14, 2017

11.0K

Related Experiment Videos

Last Updated: Apr 17, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

13.3K
Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

17.0K
Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster
12:10

Protocols for Visualizing Steroidogenic Organs and Their Interactive Organs with Immunostaining in the Fruit Fly Drosophila melanogaster

Published on: April 14, 2017

11.0K

Area of Science:

  • Plant Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Brassinosteroids are crucial plant hormones regulating growth and development.
  • Their activity can be complex, acting as both promoters and inhibitors of various processes.
  • Examples include meristem differentiation, cell expansion, stomata count, and lateral root development.

Purpose of the Study:

  • To examine the mechanisms underlying the complex phenotypic outputs of brassinosteroid activity.
  • To review how core brassinosteroid signaling components integrate with other pathways.
  • To discuss the role of spatiotemporal context in brassinosteroid-mediated growth control.

Main Methods:

  • Literature review of studies on brassinosteroid signaling.
  • Analysis of mechanisms integrating brassinosteroid pathways with peptide, hormone, and environmental signals.
  • Examination of spatiotemporal regulation of brassinosteroid activity.

Main Results:

  • Brassinosteroid signaling components integrate with diverse pathways, influencing plant development.
  • Differential activity of brassinosteroids leads to complex outcomes in organ growth and development.
  • Spatiotemporal context is a key determinant of brassinosteroid effects.

Conclusions:

  • Brassinosteroid signaling is a complex network critical for plant growth and development.
  • Understanding these integrated pathways and spatiotemporal dynamics is essential for deciphering brassinosteroid functions.
  • Further research into these mechanisms will illuminate plant adaptation and yield improvement.