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The effects of inhaled corticosteroids on growth in children

Jim Philip1

  • 1Department of Endocrinology, NMC Hospital, Al Mutradeh area, AL AIN, UAE.

The Open Respiratory Medicine Journal
|February 13, 2015
PubMed

Insights

Inhaled corticosteroids (ICS) are a first-line asthma therapy for children, effectively managing symptoms. While some ICS may slightly impact growth, their lung-focused safety is superior to oral steroids.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Growth and Development

Background:

  • Persistent asthma in children necessitates inhaled corticosteroids (ICS) for managing airway inflammation and symptoms.
  • Asthma itself, independent of treatment, can negatively impact childhood growth.
  • Assessing the impact of ICS on growth is complicated by the disease's inherent effects.

Purpose of the Study:

  • To evaluate the effects of inhaled corticosteroids on growth in children with persistent asthma.
  • To compare the growth impact of different ICS molecules and dosages.
  • To analyze the long-term effects of childhood ICS use on final adult height.

Main Methods:

  • Review of one-year studies on ICS effects on childhood growth.
  • Analysis of studies considering FDA guidance for rigorous design.
  • Examination of data on final adult height following childhood ICS exposure.

Main Results:

  • Most ICS showed a small, dose-dependent effect on childhood growth, with variations among molecules and individuals.
  • Some ICS, at studied doses and with rigorous designs, did not significantly affect growth.
  • Conflicting data exist on final adult height, but a recent study indicated an effect, necessitating further research.

Conclusions:

  • Inhaled corticosteroids are crucial for asthma control in children, offering significant benefits.
  • While measurable effects on growth exist, ICS possess a favorable safety profile compared to oral glucocorticoids.
  • Further studies are warranted to fully understand the long-term impact of ICS on final adult height.

Keywords:
Childhood asthmainhaled Corticosteroidslinear growth.

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