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Microfluidics in Assessing Platelet Function
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Factor concentrates in trauma.

Joshua M Tobin1, Kenichi A Tanaka, Charles E Smith

  • 1aDepartment of Anesthesiology, Keck Medicine, University of Southern California, Los Angeles, California bDepartment of Anesthesiology, University of Maryland, Baltimore, Maryland cDepartment of Anesthesiology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Current Opinion in Anaesthesiology
|February 13, 2015
PubMed
Summary
This summary is machine-generated.

Targeted factor concentrate therapy may improve outcomes in trauma patients with hemorrhagic shock compared to traditional ratio-based transfusions. Further prospective trials are needed to confirm these benefits.

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Area of Science:

  • Trauma resuscitation
  • Hemorrhagic shock management
  • Coagulation disorders

Background:

  • Advances in transfusion practices for hemorrhagic shock include early plasma administration, improving survival in severely injured patients.
  • Understanding the sequelae of massive transfusion highlights the need for targeted approaches to coagulation deficiencies.

Purpose of the Study:

  • To review the potential advantages of factor concentrate therapy over traditional blood product ratio-driven transfusion in trauma patients.
  • To explore the role of targeted coagulation factor replacement in managing hemorrhagic shock.

Main Methods:

  • Review of recent literature on transfusion practices and factor concentrate therapy.
  • Analysis of data from case reports, animal studies, and retrospective reviews.
  • Consideration of alternative laboratory assays like viscoelastic testing for guiding therapy.

Main Results:

  • Factor concentrate therapy allows for smaller fluid volumes and targets specific coagulation phases.
  • Existing data from case reports, animal studies, and retrospective reviews suggest factor concentrates can reverse coagulopathy and reduce blood product use.
  • Viscoelastic testing can identify specific coagulation deficiencies.

Conclusions:

  • Targeting specific coagulation phases with factor concentrates may offer benefits over ratio-driven transfusion strategies.
  • Well-powered prospective trials are necessary to demonstrate the definitive outcome benefits of factor concentrates in trauma resuscitation.