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Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report

Luca Pacini1, Daniela Bastianelli, Donatella Ponti

  • 1*Departimento di Biotecnologie e Scienze Medico-Chirurgiche, Universita' di Roma "La Sapienza" Latina 04100, Italy †Istituto Chirurgico Ortopedico Traumatologico, Latina 04100, Italy ‡Dipartimento di Medicina Molecolare, Università di Roma "La Sapienza", Roma 00161, Italy.

Applied Immunohistochemistry & Molecular Morphology : AIMM
|February 13, 2015
PubMed

Insights

Colon cancer with a novel double K-RAS mutation (codons 13 and 19) showed resistance to EGFR inhibitor therapy. This specific mutation pattern was found in mucinous-like tumor cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • K-RAS mutations in colon cancer often predict resistance to EGFR inhibitor therapies.
  • This resistance is linked to the activation of Ras-dependent intracellular signaling pathways.

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