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Related Experiment Video

Updated: Apr 17, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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One new flavonoid from Oroxylum indicum.

Qing-Fei Fan1, Zu-Yan Hu, Zhi Na

  • 1a Key Laboratory of Tropical Plant Resources and Sustainable Use , Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Kunming 650223 , P.R. China.

Natural Product Research
|February 13, 2015
PubMed
Summary
This summary is machine-generated.

A new flavonoid from Oroxylum indicum demonstrated antibacterial activity. Compounds 1 and 3 showed moderate effectiveness against Staphylococcus aureus, indicating potential for new antimicrobial drug development.

Keywords:
Oroxylum indicumantibacterial activityflavonoid

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Microbiology

Background:

  • Oroxylum indicum is a traditional medicinal plant.
  • Flavonoids are a class of plant compounds with diverse biological activities.
  • Antibacterial drug discovery is an ongoing challenge.

Purpose of the Study:

  • To isolate and characterize compounds from Oroxylum indicum.
  • To evaluate the antibacterial activity of isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation using spectral data (NMR, MS).
  • Determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against Staphylococcus aureus.

Main Results:

  • One novel flavonoid, 5,6,7-trimethoxyflavone-8-O-β-D-glucopyranoside (1), was identified.
  • Six known compounds (2-7) were also isolated and identified.
  • Compounds 1 and 3 exhibited medium antibacterial activity against Staphylococcus aureus, with MIC/MBC values ranging from 32-128 μg/ml.

Conclusions:

  • Oroxylum indicum is a source of bioactive flavonoids.
  • The isolated flavonoid 5,6,7-trimethoxyflavone-8-O-β-D-glucopyranoside shows potential as an antibacterial agent.
  • Further research is warranted to explore the therapeutic applications of these compounds.