Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Side effects of stress bleeding prophylaxis.

M Tryba1

  • 1Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University of Bochum Bergmannsheil, Federal Republic of Germany.

The American Journal of Medicine
|June 9, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

S2e guideline: positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders : Revision 2015: S2e guideline of the German Society of Anaesthesiology and Intensive Care Medicine (DGAI).

Der Anaesthesist·2015
Same author

[Short version S2e guidelines: "Positioning therapy and early mobilization for prophylaxis or therapy of pulmonary function disorders"].

Der Anaesthesist·2015
Same author

[Euthanasia and physician-assisted suicide : Attitudes of physicians and nurses].

Schmerz (Berlin, Germany)·2015
Same author

[Treatment gaps in acute pain therapy?: only a question of interpretation].

Der Anaesthesist·2013
Same author

Meta-analysis of dropout rates in randomized controlled clinical trials: opioid analgesia for osteoarthritis pain.

Schmerz (Berlin, Germany)·2011
Same author

[An algorithm for postoperative pain management in visceral and thoracic surgery: an observational study].

Zentralblatt fur Chirurgie·2011
Same journal

Mineralocorticoid Antagonists for Post-MI HFpEF: Plausible Biology Meets Low Residual Risk?

The American journal of medicine·2026
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric panniculitis.

The American journal of medicine·2026
See all related articles

Mucosa-protective drugs like sucralfate may reduce mortality in ventilated patients by preventing infections, unlike traditional antacids or histamine (H2)-antagonists. These findings highlight the importance of considering drug side effects for stress bleeding prophylaxis.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Conventional stress bleeding prophylaxis uses antacids or histamine (H2)-antagonists, with newer drugs like pirenzepine and sucralfate also available.
  • While effective for prevention, the side effects of these agents are increasingly important considerations.

Purpose of the Study:

  • To evaluate the side effect profiles of various stress bleeding prophylaxis medications.
  • To determine the impact of these drugs on infection rates and patient mortality, particularly in ventilated individuals.

Main Methods:

  • Review of existing literature on the efficacy and adverse effects of antacids, histamine (H2)-antagonists, pirenzepine, and sucralfate.
  • Analysis of studies correlating gastric juice alkalinization with bacterial colonization and pulmonary infections.

Related Experiment Videos

  • Comparison of mortality rates in ventilated patients receiving different prophylaxis strategies.

    • Main Results:

    • Histamine (H2)-antagonists carry risks including cardiac effects, CNS issues in the elderly, liver toxicity, drug interactions, and bronchoconstriction.
    • Gastric alkalinization increases bacterial colonization and pulmonary infections; sucralfate and pirenzepine may reduce these risks.
    • Sucralfate, unlike H2-antagonists or antacids, significantly reduced mortality in ventilated patients, potentially due to reduced systemic infections.

    Conclusions:

    • Sucralfate offers advantages over traditional agents in ventilated patients by reducing infection-related mortality.
    • The choice of stress bleeding prophylaxis should carefully weigh efficacy against potential side effects and infection risks.