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Does nitrous oxide affect the hemodynamic effects of anesthesia induction with propofol?
S Carlier1, H Van Aken, E Vandermeersch
1Department of Anesthesiology, University Hospital, Katholike Universiteit Leuven, Belgium.
Anesthesia and Analgesia
|June 1, 1989
Summary
This study compared propofol-based anesthesia with and without nitrous oxide in 20 patients. Nitrous oxide did not significantly alter hemodynamic parameters during propofol induction and intubation.
Area of Science:
- Anesthesiology
- Cardiovascular Physiology
Background:
- Propofol is a common induction agent for general anesthesia.
- The hemodynamic effects of propofol, particularly when combined with nitrous oxide, require careful evaluation.
Purpose of the Study:
- To compare the hemodynamic effects of propofol-based anesthesia with 100% oxygen versus 70% nitrous oxide in oxygen.
- To assess the impact of nitrous oxide on cardiac output, stroke volume, and systemic vascular resistance during anesthesia induction and intubation.
Main Methods:
- A randomized study involving 20 patients (ASA physical status I and II).
- Group A received propofol, vecuronium, and 100% oxygen.
- Group B received propofol, vecuronium, and 70% nitrous oxide in oxygen, with lorazepam premedication for all patients.
Main Results:
- Both groups showed a decrease in systolic arterial pressure, cardiac output, and stroke volume post-induction (P < 0.05).
- Systemic vascular resistance increased after intubation in both groups (P < 0.05).
- The addition of nitrous oxide did not alter the hemodynamic parameters observed during propofol induction.
Conclusions:
- Propofol induction leads to a decrease in cardiac output and stroke volume.
- Intubation causes an increase in systemic vascular resistance.
- The addition of nitrous oxide to propofol-based anesthesia does not significantly affect immediate hemodynamic responses.