Related Experiment Video
Updated: Apr 17, 2026
04:49
Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
1.3K
MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder
Rubén Fernández-Santiago1, Alex Iranzo, Carles Gaig
1Laboratory of Neurodegenerative Disorders, Department of Neurology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona; Center for Biomedical Research in Neurodegenerative Diseases, Madrid.
Annals of Neurology
|February 14, 2015
Summary
Downregulated miR-19b levels in serum indicate early Parkinson disease risk. This microRNA dysregulation occurs in the prodromal stage of synucleinopathies, preceding clinical diagnosis.
Area of Science:
- Neuroscience
- Genetics
- Biochemistry
Background:
- Parkinson disease is a synucleinopathy characterized by motor and non-motor symptoms.
- Previous research indicated decreased levels of miR-19b, miR-29a, and miR-29c in Parkinson disease patients.
- Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a prodromal synucleinopathy.
Purpose of the Study:
- To investigate the expression of miR-19b, miR-29a, and miR-29c in serum from patients with iRBD.
- To determine if miR-19b dysregulation precedes the clinical diagnosis of synucleinopathies like Parkinson disease and dementia with Lewy bodies.
Main Methods:
- Serum samples were collected from 56 patients diagnosed with iRBD.
- MicroRNA expression levels were analyzed using quantitative real-time PCR.
- Patients were followed over time to track conversion to synucleinopathies.
Main Results:
- A significant downregulation of miR-19b was observed in patients with iRBD compared to controls.
- This downregulation of miR-19b was found to antedate the diagnosis of Parkinson disease and dementia with Lewy bodies by an average of 4.67 years.
- No significant changes were noted for miR-29a and miR-29c in this cohort.
Conclusions:
- Dysregulation of miR-19b occurs during the prodromal stage of synucleinopathies.
- miR-19b may serve as a potential biomarker for early detection of synucleinopathies.
- Further research is warranted to explore the role of miR-19b in neurodegenerative disease pathogenesis.
Related Concept Videos
01:15REM Sleep Behavior Disorder
2.7K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
2.7K
01:37Neural Regulation
45.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.2K
01:24Sleep-Wake Cycles
3.5K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.5K
01:07Narcolepsy
822
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
822