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Related Experiment Videos

Lactic acidosis in theophylline overdose.

L J Leventhal1, G Kochar, N H Feldman

  • 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.

The American Journal of Emergency Medicine
|July 1, 1989
PubMed
Summary

Theophylline overdose can cause severe metabolic acidosis due to lactate buildup. Hemoperfusion effectively treated this condition, normalizing theophylline levels and resolving acidosis.

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Area of Science:

  • Toxicology
  • Clinical Medicine
  • Emergency Medicine

Background:

  • Theophylline is a medication used for respiratory diseases.
  • Theophylline overdose can lead to serious toxic effects.
  • Metabolic acidosis is a common complication of drug toxicity.

Observation:

  • An 18-year-old male presented with symptoms of theophylline overdose.
  • He developed increased anion gap metabolic acidosis with elevated serum lactate levels.
  • A correlation was noted between theophylline levels, hyperadrenergic state, and acidosis severity.

Findings:

  • Lactate accumulation was identified as a key factor in the metabolic acidosis.
  • Hemoperfusion rapidly reversed the acidosis and hyperadrenergic symptoms.

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  • Serum theophylline levels decreased significantly after hemoperfusion.

    • Implications:

    • This case highlights the critical role of lactate in theophylline-induced metabolic acidosis.
    • Early hemoperfusion is an effective treatment for severe theophylline toxicity.
    • Understanding the pathophysiology aids in managing overdose cases.