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Natural history of growth hormone deficiency in a pediatric cohort

Eva Deillon1, Michael Hauschild, Mohamed Faouzi

  • 1Division of Endocrinology, Diabetology and Obesity, University Hospital Lausanne, Lausanne, Switzerland.

Hormone Research in Paediatrics
|February 14, 2015
PubMed

Insights

Many children with growth hormone deficiency (GHD) recover by final height, but complete GHD at diagnosis and low IGF-1 levels predict continued deficiency. Pituitary malformations also indicate persistent GHD.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Deficiency
  • Endocrine Disorders

Background:

  • Childhood growth hormone deficiency (GHD) evaluation at final height remains controversial.
  • Understanding the natural history of GHD in pediatric populations is crucial for accurate diagnosis and management.
  • This study investigates the long-term outcomes of GHD in children.

Purpose of the Study:

  • To describe the natural history of growth hormone deficiency (GHD) in a pediatric cohort.
  • To identify predictors of persistent GHD into adulthood.
  • To clarify diagnostic criteria for GHD at the end of growth.

Main Methods:

  • Retrospective cohort study of pediatric patients with GHD, excluding acquired cases.
  • Univariate and multivariate logistic regression analyses were employed.
  • Predictors of GHD persistence into adulthood were identified.

Main Results:

  • Of 63 patients, 56% recovered from GHD by final height; 44% remained GH deficient.
  • Complete GHD at diagnosis, pituitary stalk defects, increased height gain during treatment, and low IGF-1 levels post-treatment predicted persistence.
  • Multivariate analysis confirmed low IGF-1 and complete GHD as significant predictors.

Conclusions:

  • A significant proportion (56%) of adolescents with GHD experience recovery by final height.
  • Complete GHD at diagnosis, low IGF-1 levels after treatment cessation, and pituitary malformations are key predictors of persistent GHD.
  • These findings aid in refining the evaluation and management of pediatric GHD.
Abstract

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