Related Experiment Videos
Effect of neuroleptic withdrawal on plasma prolactin: a possible marker of receptor adaptation
B Kirkpatrick1, R W Buchanan, K Maeda
1Maryland Psychiatric Research Center, Baltimore 21228.
Biological Psychiatry
|June 1, 1989
Abstract:
Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days. This rebound effect may be related to dopaminergic receptor changes in the tuberoinfundibular system that are induced by chronic neuroleptic administration.