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Related Concept Videos

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury II: Pathophysiology01:29

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Acute Kidney Injury VI: Nursing Management01:22

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Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
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Renal Failure: Dose Adjustments01:11

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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Related Experiment Video

Updated: Apr 17, 2026

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[Lung and kidney failure. Pathogenesis, interactions, and therapy].

S John1, C Willam2

  • 1Medizinische Klinik 4, Universität Erlangen-Nürnberg, Erlangen, Deutschland. stefan.john@uk-erlangen.de.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|February 14, 2015
PubMed
Summary

Multiple organ failure (MOF) often affects lungs and kidneys, leading to high mortality. Understanding the kidney-lung crosstalk and optimizing organ support therapies are crucial for improving patient outcomes in critical care.

Keywords:
ARDS, humanAcute kidney injuryExtracorporeal CO2-eliminationMechanical ventilationRenal replacement therapy

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Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Pulmonology

Background:

  • Multiple organ failure (MOF) frequently impacts the lungs (acute respiratory distress syndrome, ARDS) and kidneys (kidney failure), carrying a high mortality rate.
  • The precise mechanisms of MOF are not fully understood, but shared pathophysiological pathways and bidirectional harm (kidney-lung crosstalk) between these organs are implicated.
  • Inflammatory signals and volume overload contributing to edema formation are key factors in this crosstalk.

Purpose of the Study:

  • To explore the complex interactions between lung and kidney failure in the context of multiple organ failure.
  • To review the potential for organ replacement therapies to exacerbate or mitigate injury to the contralateral organ.
  • To highlight emerging therapeutic strategies aimed at reducing iatrogenic injury during organ support.

Main Methods:

  • Review of existing literature on multiple organ failure, kidney-lung crosstalk, and organ replacement therapies.
  • Analysis of the impact of mechanical ventilation and renal replacement therapy on lung and kidney function, respectively.
  • Discussion of novel extracorporeal techniques for organ support.

Main Results:

  • Organ replacement therapies, while life-saving, can induce further injury (e.g., ventilator trauma, dialyte trauma).
  • Renal replacement therapy can offer benefits to lung injury by correcting fluid and acid-base balance.
  • Emerging technologies like low-flow extracorporeal CO2 removal integrated with renal replacement platforms show promise in reducing ventilator-induced lung injury.

Conclusions:

  • The kidney-lung axis plays a critical role in the progression of multiple organ failure.
  • Careful consideration of organ replacement therapies is necessary to minimize iatrogenic harm and leverage potential benefits.
  • Advancements in extracorporeal therapies offer new avenues for managing critical illness and improving outcomes in patients with MOF.