Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

4.9K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.9K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

4
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
4
T Cell Types and Functions01:24

T Cell Types and Functions

3.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.5K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

990
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
990
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

3
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
3
Inflammation01:38

Inflammation

65.9K
Overview
65.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accident or abuse? Differential diagnosis of contact burns from radiators/heaters in children.

Forensic science, medicine, and pathology·2024
Same author

A 13-year patient journey of infant giant clival chordoma: case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2022
Same author

Explosive COVID-19 outbreak in a German nursing home and the possible role of the air ventilation system.

The Journal of hospital infection·2022
Same author

Probiotic effect of Bifidobacterium longum 5<sup>1A</sup> and Weissella paramesenteroides WpK4 on gerbils infected with Giardia lamblia.

Journal of applied microbiology·2019
Same author

[Rheumatoid arthritis].

Zeitschrift fur Rheumatologie·2018
Same author

Visfatin alters the cytokine and matrix-degrading enzyme profile during osteogenic and adipogenic MSC differentiation.

Osteoarthritis and cartilage·2018

Related Experiment Video

Updated: Apr 17, 2026

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
09:31

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Published on: October 16, 2016

10.0K

[Fibroblasts as pathogenic cells in rheumatic inflammation].

C Schönfeld1, T Pap, E Neumann

  • 1Lehrstuhl für Innere Medizin mit Schwerpunkt Rheumatologie, Rheumatologie und klinische Immunologie, Justus-Liebig-Universität Gießen, Kerckhoff-Klinik Bad Nauheim, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.

Zeitschrift Fur Rheumatologie
|February 14, 2015
PubMed
Summary

Rheumatoid arthritis (RA) involves immune cells and activated synovial fibroblasts (RASFs) driving joint destruction. RASFs actively contribute to inflammation and tissue damage in RA patients.

More Related Videos

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

10.9K
Ultrasonic-augmented Primary Adult Fibroblast Isolation
06:51

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

8.4K

Related Experiment Videos

Last Updated: Apr 17, 2026

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
09:31

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Published on: October 16, 2016

10.0K
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

10.9K
Ultrasonic-augmented Primary Adult Fibroblast Isolation
06:51

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

8.4K

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Context:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • RA is characterized by synovitis, synovial hyperplasia, and joint degeneration.
  • Immune cells and synovial fibroblasts mediate these pathological processes.

Purpose:

  • To elucidate the role of rheumatoid arthritis synovial fibroblasts (RASFs) in RA pathogenesis.
  • To understand how RASFs contribute to joint inflammation and destruction.
  • To highlight the active role of RASFs beyond passive response.

Summary:

  • RASFs in RA patients exhibit an activated phenotype with altered adhesion molecule expression.
  • Activated RASFs synthesize proteases, leading to cartilage and bone destruction.
  • RASFs produce cytokines and chemokines, promoting inflammation and immune cell recruitment.
  • These cells actively contribute to the inflammatory milieu, transforming into an aggressive phenotype.

Impact:

  • RASFs are identified as key players in RA's chronic, destructive inflammatory response.
  • Understanding RASF behavior offers potential therapeutic targets for RA.
  • This research deepens insight into the cellular mechanisms driving autoimmune joint disease.