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Updated: Apr 17, 2026
09:31
Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients
Published on: October 16, 2016
10.0K
[Fibroblasts as pathogenic cells in rheumatic inflammation]
C Schönfeld1, T Pap, E Neumann
1Lehrstuhl für Innere Medizin mit Schwerpunkt Rheumatologie, Rheumatologie und klinische Immunologie, Justus-Liebig-Universität Gießen, Kerckhoff-Klinik Bad Nauheim, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.
Zeitschrift Fur Rheumatologie
|February 14, 2015
Summary
Rheumatoid arthritis (RA) involves immune cells and activated synovial fibroblasts (RASFs) driving joint destruction. RASFs actively contribute to inflammation and tissue damage in RA patients.
Area of Science:
- Immunology
- Rheumatology
- Cell Biology
Context:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- RA is characterized by synovitis, synovial hyperplasia, and joint degeneration.
- Immune cells and synovial fibroblasts mediate these pathological processes.
Purpose:
- To elucidate the role of rheumatoid arthritis synovial fibroblasts (RASFs) in RA pathogenesis.
- To understand how RASFs contribute to joint inflammation and destruction.
- To highlight the active role of RASFs beyond passive response.
Summary:
- RASFs in RA patients exhibit an activated phenotype with altered adhesion molecule expression.
- Activated RASFs synthesize proteases, leading to cartilage and bone destruction.
- RASFs produce cytokines and chemokines, promoting inflammation and immune cell recruitment.
- These cells actively contribute to the inflammatory milieu, transforming into an aggressive phenotype.
Impact:
- RASFs are identified as key players in RA's chronic, destructive inflammatory response.
- Understanding RASF behavior offers potential therapeutic targets for RA.
- This research deepens insight into the cellular mechanisms driving autoimmune joint disease.
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