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Rat liver gamma glutamyl transpeptidase mRNA differs in the 5' untranslated sequence from the corresponding kidney
1MRC Toxicology Unit, Carshalton, Surrey, U.K.
Cancer Letters
|July 1, 1989
Abstract:
A clone containing the entire protein-coding region of gamma glutamyl transpeptidase (GGT) from ethoxyquin- (EQ) treated rat liver has been isolated from a cDNA library. DNA sequence analysis showed that the protein-coding and 3' untranslated regions are almost identical to rat kidney GGT, but the sequences differ in the 5' untranslated region. Southern blot data suggest a single gene for GGT in the rat, hence the different mRNAs may originate by differential transcriptional and/or posttranscriptional processing.