Bone marrow-derived mesenchymal stem cells in the treatment of myocardial infarction

Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to regenerate myocadial tissue. BMSCs transplantation can produce cardiac-like cells,promote angiogenesis, and secrete a variety of growth factors and cytokines. This article summarizes the molecular mechanisms of myocardial repair, explores the potential regenerative capacity of cardiac muscles after myocardial infarction,and reviews the previous studies on BMSC transplantation for treatment of cardiac muscle after myocardial infarction, with an attempt to provide new insights in clinical decision-making.