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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
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Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

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An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Related Experiment Video

Updated: Apr 17, 2026

Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice

Published on: April 2, 2013

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Platelets: the few, the young, and the active.

Carol D'Souza1, Carol Briggs2, Samuel J Machin3

  • 1Biomedical Sciences, Faculty of Science & Technology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.

Clinics in Laboratory Medicine
|February 14, 2015
PubMed
Summary
This summary is machine-generated.

Modern automated cell counters enhance platelet analysis using advanced technologies like fluorescent dyes and monoclonal antibodies. These innovations ensure accurate platelet counts, even in patients with low platelet levels, and introduce new measurement parameters.

Keywords:
Automated platelet countingMPVReticulated platelets

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Routine Screening Method for Microparticles in Platelet Transfusions
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Real-time Imaging of Heterotypic Platelet-neutrophil Interactions on the Activated Endothelium During Vascular Inflammation and Thrombus Formation in Live Mice
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Area of Science:

  • Hematology
  • Clinical Laboratory Science
  • Biotechnology

Background:

  • Routine platelet analysis is critical in high-volume clinical hematology laboratories.
  • Traditional methods face challenges in accurately enumerating platelets, especially in thrombocytopenic patients.

Observation:

  • Modern automated cell counters incorporate advanced technologies for platelet counting.
  • These technologies include information technology, fluorescent dyes, and monoclonal antibodies.

Findings:

  • Improved technologies lead to more reliable and precise platelet enumeration.
  • Accurate counts are achievable even in patients with thrombocytopenia (low platelet count).
  • Novel platelet parameters can now be reported.

Implications:

  • Enhanced diagnostic capabilities for hematological disorders.
  • Potential for earlier and more accurate detection of conditions affecting platelet levels.
  • Future advancements in digital image analysis may further refine platelet analysis.