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Creeping proteins in microporous structures: polymer brush-assisted fabrication of 3D gradients for tissue
Michel Klein Gunnewiek1, Andrea Di Luca2, Hermannes Z Bollemaat1
1Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500, AE, Enschede, The Netherlands.
Abstract:
Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments.
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