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Related Experiment Videos

Ramp work tests with three different beta-blockers in normal human subjects.

R L Hughson1

  • 1Department of Kinesiology, University of Waterloo, Ontario, Canada.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1989
PubMed
Summary

Beta-blockade significantly impairs heart rate (HR) response during exercise but does not affect oxygen uptake (VO2) or blood lactate (La-) kinetics in healthy males. Exercise capacity remains largely preserved despite reduced HR during ramp tests.

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Area of Science:

  • Exercise Physiology
  • Cardiovascular Pharmacology
  • Sports Medicine

Background:

  • Beta-blockers are commonly prescribed for cardiovascular conditions.
  • Their impact on physiological responses during exercise, particularly oxygen uptake and lactate accumulation, requires detailed investigation.
  • Understanding these effects is crucial for managing exercise in patients on beta-blocker therapy.

Purpose of the Study:

  • To investigate the dose-dependent effects of beta-blockade on oxygen uptake (VO2), heart rate (HR), and blood lactate (La-) responses during ramp exercise.
  • To determine if beta-blockade alters the kinetics of VO2 and La- during incremental exercise.

Main Methods:

  • Eight healthy male volunteers performed ramp cycle ergometer tests.
  • Subjects received placebo or varying doses of propranolol, metoprolol, or oxprenolol.

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  • VO2, HR, and La- were measured, with kinetic parameters (TLT, slope, LSI) derived using regression and exponential models.

    • Main Results:

    • Beta-blockade significantly reduced submaximal HR and altered HR total lag time (TLT) in a dose-dependent manner.
    • The slope of the HR vs. work rate relationship was significantly depressed by beta-blockade.
    • VO2 kinetics (TLT and slope) and lactate slope index (LSI) were largely unaffected by beta-blockade, except for a reduced VO2 slope at the highest dose.

    Conclusions:

    • Beta-blockade markedly impairs the heart rate response to incremental exercise.
    • Despite significant HR impairment, oxygen uptake and blood lactate responses during ramp exercise are relatively preserved.
    • These findings suggest that exercise capacity may be maintained during beta-blocker therapy due to compensatory mechanisms in VO2 and La- regulation.