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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Related Experiment Video

Updated: Apr 17, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
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Compromised white matter integrity in obesity.

S Kullmann1, F Schweizer, R Veit

  • 1Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University of Tübingen, Tübingen, Germany; German Center for Diabetes Research, Neuherberg, Germany; Institute of Medical Psychology and Behavioral Neurobiology, fMEG Center, University of Tübingen, Tübingen, Germany.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|February 14, 2015
PubMed
Summary

Obesity impacts brain white matter integrity, particularly in key pathways. Diffusion tensor imaging reveals that higher body mass index (BMI) is linked to reduced white matter quality, suggesting accelerated brain aging in obese individuals.

Keywords:
Braindiffusion tensor imagingobesitywhite matter

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Area of Science:

  • Neuroscience
  • Radiology
  • Public Health

Background:

  • Obesity is linked to central nervous system structural and functional changes.
  • Gray matter shows consistent reductions with increasing body mass index (BMI).
  • White matter volumetric changes in obesity are complex and less conclusive.

Purpose of the Study:

  • To review the relationship between obesity and brain alterations using diffusion tensor imaging (DTI).
  • To investigate microstructural white matter changes associated with obesity.

Main Methods:

  • Utilized diffusion tensor imaging (DTI) to assess white matter integrity.
  • Analyzed parameters of diffusivity and anisotropy, focusing on fractional anisotropy (FA).
  • Reviewed studies examining the association between BMI and brain structure.

Main Results:

  • Obesity-related factors are associated with a loss of white matter integrity.
  • Reduced white matter integrity observed in limbic system tracts and frontotemporal connections.
  • Inverse association found between BMI and FA in corpus callosum, fornix, cingulum, and corona radiata across age groups.
  • Significant BMI and age interactions suggest accelerated white matter aging in obese individuals.

Conclusions:

  • DTI is a sensitive tool for detecting obesity-related white matter microstructural changes.
  • Obesity is associated with widespread white matter integrity loss, particularly in specific brain tracts.
  • Obesity may accelerate the aging process of brain white matter structure.