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Progesterone administration in patients with absent ovaries
P Devroey1, G Palermo, C Bourgain
1Centre for Reproductive Medicine, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
International Journal of Fertility
|May 1, 1989
Summary
Vaginal progesterone administration effectively prepares the endometrium for pregnancy, similar to intramuscular injections. Oral progesterone was insufficient for adequate endometrial secretory patterns in women undergoing oocyte donation.
Area of Science:
- Reproductive Endocrinology
- Gynecology
Background:
- Hormone replacement therapy is crucial for women with absent ovaries undergoing assisted reproduction.
- Progesterone plays a vital role in preparing the endometrium for embryo implantation.
Purpose of the Study:
- To compare the endometrial receptivity and serum progesterone levels following different routes of progesterone administration.
- To determine the optimal progesterone regimen for women with absent ovaries undergoing oocyte donation.
Main Methods:
- Forty-four women with absent ovaries received oestradiol valerate and various progesterone regimens.
- Progesterone was administered intramuscularly (100 mg), orally (300 mg), or vaginally (300 mg or 600 mg).
- Endometrial histology and serum progesterone levels were assessed on day 21 of stimulated luteal phases.
Main Results:
- Oral progesterone (300 mg) did not induce an adequate secretory endometrium.
- Intramuscular (100 mg) and vaginal (300-600 mg) progesterone resulted in similar, adequate endometrial patterns.
- Serum progesterone levels were five times higher after intramuscular injection compared to vaginal administration.
Conclusions:
- Vaginal administration of micronized progesterone (300-600 mg) is a viable alternative to intramuscular injections for endometrial preparation.
- Oral progesterone is not recommended for achieving adequate endometrial secretory patterns in this patient population.