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Related Experiment Video

Updated: Apr 17, 2026

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
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Predicting bacteraemia in validated models--a systematic review.

N Eliakim-Raz1, D W Bates2, L Leibovici3

  • 1Unit of Infectious Diseases Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|February 14, 2015
PubMed
Summary

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This summary is machine-generated.

Predicting bloodstream infections (Bacteraemia) is crucial. While models exist, limited external validation and lack of clinical use hinder their impact on patient care and healthcare costs.

Area of Science:

  • Medical Diagnostics
  • Clinical Epidemiology

Background:

  • Bacteraemia (bloodstream infection) is a serious condition with high mortality rates.
  • Numerous models exist to predict bacteraemia, but their validation and clinical utility are inconsistent.

Purpose of the Study:

  • To identify validated models for predicting bacteraemia in adults.
  • To assess their success in identifying low/high-risk groups and their adoption in clinical practice.

Main Methods:

  • Systematic search of electronic databases for validated bacteraemia prediction models.
  • Inclusion of studies defining low (<3%) or high (>30%) bacteraemia probabilities.
  • Analysis of internal and external validation results and author contact regarding clinical implementation.
Keywords:
Bacterial bloodstream infectionsblood culturesprediction modelssepsisvalidation

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Main Results:

  • Fifteen publications involving 59,276 patients met criteria; models showed good internal validation.
  • External validation was performed in twelve studies, with five models performing well in independent datasets.
  • None of the validated models have been implemented in clinical practice.

Conclusions:

  • Heterogeneous studies with limited external validation exist for bacteraemia prediction.
  • Models could reduce unnecessary blood cultures, saving costs and improving patient care.
  • Further multicenter clinical trials are needed to establish the utility and safety of these models in diverse settings.