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TORCH infections

Natalie Neu1, Jennifer Duchon2, Philip Zachariah2

  • 1Division of Pediatric Infectious Disease, Columbia University Medical Center, 622 West 168th Street, PH-468, New York, NY 10032, USA.

Clinics in Perinatology
|February 14, 2015
PubMed

Insights

TORCH infections, including toxoplasmosis and parvovirus B19, significantly impact maternal and child health globally. Early detection and available interventions are crucial for preventing severe outcomes.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • TORCH infections pose significant global health challenges, particularly in low- and middle-income countries.
  • These infections contribute substantially to prenatal, perinatal, and postnatal morbidity and mortality.
  • Clinical manifestations can appear at birth, in infancy, or manifest years later.

Purpose of the Study:

  • To review the epidemiology and clinical significance of key TORCH infections.
  • To highlight the importance of early recognition and available management strategies.
  • To cover specific infections: toxoplasmosis, parvovirus B19, syphilis, rubella, hepatitis B, hepatitis C, and HIV.

Main Methods:

  • Literature review of TORCH infections.
  • Focus on epidemiological trends and clinical impact.
  • Synthesis of information on prevention and treatment.

Main Results:

  • TORCH infections represent a major cause of adverse outcomes in newborns and infants.
  • Varied presentation timelines necessitate ongoing surveillance.
  • Effective prevention and treatment options exist for many pathogens.

Conclusions:

  • Early identification through prenatal screening is critical for managing TORCH infections.
  • Prompt intervention can mitigate severe morbidity and mortality.
  • Understanding the epidemiology guides public health strategies.
Keywords:
HIVHepatitis BHepatitis CParvovirusRubellaTORCHToxoplasmosisTreponema pallidum

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