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Primary lymphomas in the gastrointestinal tract
Jiang Chen Peng1, Lu Zhong, Zhi Hua Ran
1State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai Inflammatory Bowel Disease Research Center, Shanghai, China.
Journal of Digestive Diseases
|February 14, 2015
Summary
Primary gastrointestinal lymphomas are rare conditions affecting the entire digestive tract. This review covers their epidemiology, clinical features, and treatment, focusing on common subtypes like diffuse large B-cell lymphoma (DLBCL) and MALT lymphoma.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Primary gastrointestinal (GI) lymphomas are uncommon malignancies.
- Etiologies are unclear, with risk factors including celiac disease, H. pylori, immunosuppression, HIV, EBV, and IBD.
- DLBCL and MALT lymphoma are the most frequent GI lymphoma subtypes.
Purpose of the Study:
- To review the epidemiology, histology, clinical manifestations, endoscopic and radiological features, and treatment of GI lymphomas.
- To provide a comprehensive overview of lymphomas affecting the esophagus, stomach, and intestine.
Main Methods:
- Literature review of primary GI lymphomas.
- Synthesis of data on epidemiology, risk factors, subtypes, and clinical presentation.
- Compilation of diagnostic features (histology, endoscopy, radiology) and treatment modalities.
Main Results:
- GI lymphomas involve the entire GI tract; DLBCL and MALT lymphoma are most common.
- Geographical variations exist: B-cell lymphomas are more prevalent in the West, T-cell lymphomas in Asia-Pacific.
- The review details various aspects from epidemiology to treatment for esophageal, gastric, and intestinal lymphomas.
Conclusions:
- Primary GI lymphomas encompass a range of B-cell and T-cell malignancies with diverse presentations.
- Understanding epidemiological variations and risk factors is crucial for diagnosis and management.
- This review consolidates key information for clinicians and researchers in the field.
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