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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Liposomes as nanomedical devices.

Giuseppina Bozzuto¹, Agnese Molinari²

¹Chemical Methodology Institute, CNR, Rome, Italy ; Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.

International Journal of Nanomedicine

|February 14, 2015

Summary

Liposomes are highly successful drug carriers due to their biological advantages. This review analyzes how liposome properties influence their efficacy and explores strategies to improve their therapeutic applications.

Keywords:

drug delivery liposomes nanomedicine ultrastructure

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Area of Science:

Biotechnology
Pharmaceutics
Nanomedicine

Background:

Liposomes, discovered in the 1960s, are extensively researched drug carriers.
They are recognized for significant biological and technological advantages in drug delivery.
Several liposomal drug applications are approved, in clinical trials, or nearing market release.

Purpose of the Study:

To review the critical factors influencing liposome efficacy.
To discuss the impact of physicochemical properties on liposome performance in vivo.
To explore strategies for overcoming limitations of early liposome formulations.

Main Methods:

Literature review of liposome research.
Analysis of structure-property relationships in liposomes.
Examination of in vivo behavior and cellular interactions of liposomes.

Main Results:

Liposome efficacy is dependent on component nature, size, surface charge, and lipid organization.
Physicochemical properties significantly affect cellular interactions, half-life, tissue penetration, and in vivo fate.
Strategies exist to enhance liposome performance beyond first-generation formulations.

Conclusions:

Liposomes remain a leading drug carrier system with ongoing advancements.
Understanding liposome properties is key to optimizing drug delivery and therapeutic outcomes.
Further development promises expanded clinical applications for liposome-based therapies.