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Updated: Apr 17, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Lennox-lombroso lecture, 2013: psychiatric comorbidities through the life of the seizure disorder: a complex relation
1Department of Neurology, Epilepsy Section and Comprehensive Epilepsy Center, University of Miami Miller School of Medicine, Miami, FL.
Abstract:
Psychiatric comorbidities are relatively frequent in people with epilepsy, occurring in one of every three patients, with mood and anxiety disorders predominating. They are the expression of a complex interaction between a previous psychiatric history (and/or genetic predisposition for psychiatric disorder), neurobiologic changes associated with the underlying epilepsy, peri-ictal phenomena, iatrogenic and reactive processes. Furthermore, a bidirectional relation between psychiatric disorders and epilepsy has added another level of complexity, while at the same time opening an opportunity of the recognition of potential pathogenic mechanisms that are responsible for the high comorbid occurrence of these disorders. This article highlights the clinical implications of understanding the course of psychiatric comorbidities relative to the onset of the seizure disorder to minimize their risk of recurrence and their interference in the management of the seizure disorder.
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