Related Experiment Video
Updated: Apr 17, 2026

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
Cooperative binding of ferrocenylnaphthalene diimide carrying β-cyclodextrin converts double-stranded DNA to a
Shinobu Sato1, Yuta Umeda1, Satoshi Fujii1
1†Department of Applied Chemistry, ‡Research Center for Biomicrosensing Technology, and §Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu, Fukuoka 804-8550, Japan.
Abstract:
Ferrocenylnaphthalene diimide carrying β-cyclodextrin (β-CD), 1, intercalated into double-stranded DNA with a binding affinity of K = (6.6 ± 0.8) × 10(4) M(-1) and a binding site size of n = 4, with a high positive cooperative parameter of ω = 14. β-CD and ferrocene moieties of the compound contributed to the formation of the intermolecular inclusion complex on DNA. Binding of 1 resulted in conversion of the DNA duplex to a rod-like form, which was cleaved upon adamantylamine addition.
Related Concept Videos
Cooperative Binding of Transcription Regulators
Single-Strand DNA Binding Proteins
Nucleic Acid Structure
DNA Structure
DNA...

