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Updated: Apr 17, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Intermolecular hydroaminoalkylation of alkenes and dienes using a titanium mono(formamidinate) catalyst
Jaika Dörfler1, Till Preuss, Christian Brahms
1Institut für Chemie, Universität Oldenburg, Carl-von-Ossietzky-Strasse 9-11, D-26111 Oldenburg, Germany. doye@uni-oldenburg.de.
Abstract:
An easily accessible formamidinate ligand-bearing titanium complex initially synthesized by Eisen et al. is used as catalyst for intermolecular hydroaminoalkylation reactions of unactivated, sterically demanding 1,1- and 1,2-disubstituted alkenes and styrenes with secondary amines. The corresponding reactions, which have never been achieved with titanium catalysts before, take place with excellent regioselectivity (up to 99 : 1) and in addition, corresponding reactions of 1,3-butadienes with N-methylbenzylamine are also described for the first time.
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