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Updated: Apr 17, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Orbital Metastasis of Undifferentiated/Anaplastic Thyroid Carcinoma
Divakar Gupta1, Michael Chappell, Tina D Tailor
1*Department of Ophthalmology, University of Washington Eye Institute; †Department of Radiology, University of Washington Medical Center, ‡Department of Pathology, and §Department of Otolaryngology-Head and Neck Surgery, University of Washington Medical Center, Seattle, Washington, U.S.A.
Abstract:
A 52-year-old woman presented with decreased vision, diplopia, esotropia, proptosis, and right orbital pain. Clinical examination was suspicious for an orbital mass and additionally revealed a thyroid gland mass. Imaging studies showed an enhancing mass within the right lateral rectus muscle and a heterogeneous mass in the left lobe of the thyroid gland. Excisional biopsies of the thyroid and orbital lesions were consistent with metastatic undifferentiated/anaplastic thyroid carcinoma. This represents the first reported case of undifferentiated/anaplastic thyroid carcinoma metastatic to the orbit.
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