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Updated: Apr 17, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
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Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

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Autism and intellectual disability associated with mitochondrial disease and hyperlactacidemia

José Guevara-Campos1, Lucía González-Guevara2, Omar Cauli3

  • 1Felipe Guevara Rojas" Hospital, Pediatrics Service, University of Oriente, El Tigre-Anzoátegui, 6034 Venezuela, Spain. joguevara90@hotmail.com.

International Journal of Molecular Sciences
|February 14, 2015
PubMed
Summary

Children with autism spectrum disorder (ASD) and intellectual disability (ID) showing hyperlactacidemia may have mitochondrial disorders. Early evaluation and cofactor treatments show partial benefits, warranting further research.

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