Seizures, refractory status epilepticus, and depolarization block as endogenous brain activities

Kenza El Houssaini1, Anton I Ivanov1, Christophe Bernard1

  • 1Aix Marseille Université, Inserm, INS UMR_S 1106, 13005, Marseille, France.

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Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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