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Enzyme-responsive protein/polysaccharide supramolecular nanoparticles.

Xiao-Fang Hou1, Yong Chen, Yu Liu

  • 1Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.

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Novel biocompatible nanoparticles made of sulfato-β-cyclodextrin (SCD) and protamine are enzyme-responsive. These nanoparticles efficiently release encapsulated substances upon exposure to trypsin, enabling controlled drug delivery.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Enzyme-responsive supramolecular assemblies are of increasing interest for targeted drug delivery.
  • Controlled release mechanisms are crucial for localized therapeutic applications.

Purpose of the Study:

  • To construct novel enzyme-responsive supramolecular nanoparticles using biocompatible materials.
  • To investigate the enzyme-triggered disassembly and drug release capabilities of these nanoparticles.

Main Methods:

  • Supramolecular nanoparticles were assembled from sulfato-β-cyclodextrin (SCD) and protamine via non-covalent interactions.
  • Nanoparticle characterization was performed using atomic force microscopy (AFM) and transmission electron microscopy (TEM).
  • Enzyme responsiveness was assessed by evaluating nanoparticle disassembly in the presence of various enzymes, with a focus on trypsin.

Main Results:

  • Novel biocompatible supramolecular nanoparticles were successfully synthesized from SCD and protamine.
  • The nanoparticles demonstrated specific responsiveness and disassembly triggered by trypsin, outperforming other enzymes.
  • Efficient and controlled release of an encapsulated model substrate was achieved due to trypsin-induced disassembly.

Conclusions:

  • The developed SCD-protamine nanoparticles offer a stable platform for encapsulating therapeutic agents.
  • Trypsin-triggered disassembly enables precise and controlled release of cargo at specific enzyme-rich sites.
  • These findings highlight the potential of these nanoparticles for targeted enzyme-responsive drug delivery applications.