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[Laboratory surveillance of Streptococcus pneumoniae from invasive disease, Chile 2007-2012]

M Teresa Valenzuela, Mabel Seoane, Andrea Canals

    Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
    |February 14, 2015
    PubMed

    Insights

    The 10-valent pneumococcal vaccine (PCV-10) significantly reduced invasive pneumococcal disease (IPD) in Chile. Surveillance data from 2007-2012 shows a notable decrease in IPD incidence, particularly in young children.

    Area of Science:

    • Public Health
    • Infectious Diseases
    • Vaccinology

    Background:

    • Chile introduced the 10-valent pneumococcal vaccine (PCV-10) in 2011, initially as a 4-dose program, later modified to 3 doses in 2012.
    • This study analyzes data from the Laboratory Surveillance System for Streptococcus pneumoniae causing invasive disease between 2007 and 2012.

    Purpose of the Study:

    • To evaluate the impact of the PCV-10 vaccine on the incidence of invasive pneumococcal disease (IPD) in Chile.
    • To compare IPD incidence across different age groups during the pre-vaccinal and post-vaccinal periods.

    Main Methods:

    • A descriptive study was conducted using data from the National Reference Laboratory of the Institute of Public Health of Chile.
    • Surveillance data for Streptococcus pneumoniae isolated from invasive disease cases between 2007 and 2012 was analyzed.

    Main Results:

    • Global incidence of laboratory-confirmed IPD cases decreased by 27.8% from 2007 to 2012.
    • Incidence in infants (≤1 year) dropped from 56.1 to 16.3 per 100,000, and in children aged 12-23 months from 42.0 to 19.9 per 100,000.
    • Significant reductions were observed for specific serotypes, including 4 (100%), 19F (93.3%), and 23F (90.9%), in children under two years old.

    Conclusions:

    • The Laboratory Surveillance System effectively monitors Streptococcus pneumoniae in invasive diseases, providing crucial data on IPD trends and serotype prevalence.
    • The findings demonstrate the positive impact of PCV-10 on reducing IPD and can inform future healthcare decisions regarding pneumococcal vaccination strategies.
    Abstract

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