Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in eye tracking during clinical stabilization in schizophrenia.

M M Rea1, J A Sweeney, C M Solomon

  • 1Dept. of Psychology, UCLA 90024-1563.

Psychiatry Research
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of insulation with bubble wrap and an absorbent pad on heat loss in anaesthetised cats.

New Zealand veterinary journal·2020
Same author

A survey of dog and cat anaesthesia in a sample of veterinary practices in New Zealand.

New Zealand veterinary journal·2017
Same author

Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

Translational psychiatry·2017
Same author

Deviation from expected cognitive ability across psychotic disorders.

Schizophrenia research·2017
Same author

Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders.

Translational psychiatry·2016
Same author

5HT<sub>2A</sub> receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice.

Genes, brain, and behavior·2016

Eye tracking pursuit accuracy is stable in schizophrenia patients, suggesting a trait marker. However, saccade frequency and size change during illness, indicating state-dependent characteristics.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Ophthalmology

Background:

  • Eye tracking abnormalities are potential trait markers for schizophrenia.
  • Previous studies focused on stable patients, lacking insight into acute illness phases.
  • Limited analysis of different eye movement types in schizophrenia.

Purpose of the Study:

  • To investigate eye tracking stability during acute schizophrenic episodes.
  • To analyze changes in pursuit accuracy and saccades over four weeks.
  • To correlate eye movement changes with clinical state and neuroleptic dosage.

Main Methods:

  • Longitudinal study of nine recently hospitalized schizophrenic patients over four weeks.
  • Qualitative assessment of eye tracking pursuit accuracy.

Related Experiment Videos

  • Quantification of saccade frequency and size.
  • Monitoring of clinical state and neuroleptic dose.

    • Main Results:

    • Pursuit accuracy remained stable in patients and controls over time.
    • Saccade frequency significantly increased, with more small saccades and fewer large saccades.
    • Reduced large saccades correlated strongly with increased neuroleptic dose.

    Conclusions:

    • Eye tracking pursuit accuracy may represent a stable trait characteristic in schizophrenia.
    • Saccade frequency and size appear to be state-dependent, influenced by illness and medication.
    • Findings differentiate trait vs. state characteristics of eye movement abnormalities in schizophrenia.