Adaptive Cosegmentation of Pheochromocytomas in CECT Images Using Localized Level Set Models

Segmentation of pheochromocytomas in contrast-enhanced computed tomography (CECT) images is an ill-posed problem due to the presence of weak boundaries, intratumoral degeneration, and nearby structures and clutter. Additional information from different phases of CECT images needs to be imposed for better mass segmentations. In this paper, a novel adaptive cosegmentation method is proposed by incorporating a localized region-based level set model (LRLSM). The energy function is formulated with consideration of adaptive tradeoff between the complementary local information from image pairs. Gradient direction and shape dissimilarity measure are integrated to guide the level set evolution. Automatic localization radius selection is added to further facilitate the segmentation. Then, two level set functions from each image pair are evolved and refined alternately to minimize the energy function. Experimental results in 50 CECT image pairs show that the adaptive LRLSM-based method is effective in segmentation of pheochromocytoma at two phases and produces better results, especially in the cases with weak boundaries, and complex foreground and background.