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Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

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Stimuli-responsive and hemocompatible pseudozwitterionic interfaces.

Antoine Venault¹, Yong-Sheng Zheng, Arunachalam Chinnathambi

¹R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University , Jhong-Li, Taoyuan 320, Taiwan.

Langmuir : the ACS Journal of Surfaces and Colloids

|February 15, 2015

Summary

This summary is machine-generated.

Researchers developed new hydrogels using N-isopropylacrylamide (NIPAAm) and charged monomers (TMA/SA). These materials resist biofouling and show excellent hemocompatibility, making them promising for biomedical applications.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Surface Science

Background:

Developing hemocompatible materials is crucial for medical devices.
Biofouling on implantable materials leads to device failure.
Stimuli-responsive hydrogels offer tunable surface properties.

Purpose of the Study:

To create novel hemocompatible hydrogel interfaces.
To investigate the effect of copolymer composition on biofouling resistance.
To evaluate the hemocompatibility of designed hydrogels.

Main Methods:

Synthesized poly(NIPAAm-co-TMA/SA) hydrogels with varying NIPAAm and mixed-charge (TMA/SA) ratios.
Assessed hydrogel swelling behavior under different environmental conditions (temperature, pH, ionic strength).
Evaluated biofouling resistance against plasma proteins, bacteria, platelets, and whole blood.
Measured hemolytic activity and plasma clotting time to determine hemocompatibility.

Main Results:

Hydrogel resistance to biofouling increased with higher TMA/SA content, achieving non-biofouling properties at 100% TMA/SA.
Stimuli-responsive hydrogels demonstrated reduced adhesion of proteins, bacteria, and platelets.
The hydrogels exhibited low hemolytic activity (0.5%) and a long plasma clotting time (10 min), indicating excellent hemocompatibility.
Hydrogels with both NIPAAm and TMA/SA showed preferential leukocyte adhesion.

Conclusions:

Well-defined compositions of NIPAAm and pseudozwitterionic TMA/SA in hydrogels yield excellent hemocompatibility and tunable biofouling resistance.
These stimuli-responsive hydrogels are promising for biomedical applications requiring reduced biofouling and good blood compatibility.
The preferential leukocyte adhesion warrants further investigation for specific applications like targeted drug delivery or immune response modulation.