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Updated: Apr 17, 2026

Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
Age-related infertility
Natalie M Crawford1, Anne Z Steiner1
1Reproductive Endocrinology and Infertility, University of North Carolina, 4001 Old Clinic Building, CB 7570, Chapel Hill, NC 27599, USA.
Abstract:
Oocyte number and quality decrease with advancing age. Thus, fecundity decreases as age increases, with a more rapid decline after the mid-30s. Patients more than 35 years old should receive prompt evaluation for causes of infertility after no more than 6 months of attempted conception. Patients with abnormal tests of ovarian reserve have a poorer prognosis and may need more expedited and aggressive treatment. Although oocyte donation is the best method to overcome age-related infertility, other treatment options may help women proceed quicker toward pregnancy. Patients at an advanced age should be counseled and evaluated before undergoing infertility treatments.
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