Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.8K
Cell Migration01:09

Cell Migration

19.3K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.3K
Cell Migration01:19

Cell Migration

7.6K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.6K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.5K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.5K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.8K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

10.4K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.

EMBO reports·2026
Same author

Trans-dimerization of Amyloid Precursor Protein family members induces pre- and postsynaptic differentiation through distinct signaling pathways.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

GPCR kinases shape ACKR4 functions via differential C-terminal phosphorylation.

Nature communications·2026
Same author

Distinct dendritic cell cytoskeletal programs dictate synapse architecture and CD8<sup>+</sup> T cell fate.

Frontiers in immunology·2026
Same author

Intact lymph node homing and CD8<sup>+</sup> T-cell priming abilities of Sprouty2-deficient dendritic cells.

Frontiers in immunology·2026
Same author

Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion.

Nature cell biology·2026

Related Experiment Video

Updated: Apr 17, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K

On the move: endocytic trafficking in cell migration.

Tanja Maritzen1, Hannah Schachtner, Daniel F Legler

  • 1Leibniz Institute for Molecular Pharmacology, Robert-Roessle-Str. 10, 13125, Berlin, Germany, maritzen@fmp-berlin.de.

Cellular and Molecular Life Sciences : CMLS
|February 16, 2015
PubMed
Summary

Cellular trafficking, particularly endocytosis, is crucial for directed cell migration. This process influences chemokine signaling, integrin dynamics, and extracellular matrix remodeling, impacting functions from healing to metastasis.

More Related Videos

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

13.1K
In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

142.2K

Related Experiment Videos

Last Updated: Apr 17, 2026

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K
Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

13.1K
In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

142.2K

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Directed cell migration is vital for physiological processes like wound healing and immune responses, as well as pathological conditions such as cancer metastasis.
  • Endocytic trafficking has emerged as a critical regulator of cell migration, influencing multiple molecular and cellular events.

Purpose of the Study:

  • To review recent advancements in understanding the role of cellular trafficking pathways in directed cell migration.
  • To highlight the intricate connections between endocytic processes and cell motility.

Main Methods:

  • Literature review of recent studies on cell migration and endocytic trafficking.
  • Synthesis of findings related to chemokine receptors, integrin dynamics, and extracellular matrix remodeling.

Main Results:

  • Endocytic trafficking modulates cell migration by regulating chemokine receptor levels, integrin delivery, and focal adhesion turnover.
  • Endosomal pathways are essential for the reorganization of the extracellular matrix, including the activity of matrix metalloproteases.
  • Key regulators of endocytic trafficking are also critical for cell migration.

Conclusions:

  • Cellular trafficking pathways, especially endocytosis, play a multifaceted and essential role in directed cell migration.
  • Understanding these trafficking mechanisms offers potential therapeutic targets for diseases involving aberrant cell motility.