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Updated: Apr 17, 2026
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Is primary tumor detectable in prostatic carcinoma at routine contrast-enhanced CT?
Nicola Schieda1, Omran Al-Dandan2, Wael Shabana2
1The Ottawa Hospital, The University of Ottawa, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9.
Objectives:
To determine if prostatic carcinoma (PCa) is detectable at routine contrast-enhanced CT (CECT).
Materials And Methods:
With institutional review board approval, 63 consecutive PCa patients underwent CECT before therapy. Two blinded radiologists assessed for rounded focal enhancing peripheral zone nodules. Diagnostic accuracy and inter-observer agreement were compared by Gleason Score (GS).
Results:
Overall sensitivity was 63-76% with moderate agreement, K=0.42. The false-positive rate was 15%. Sensitivities and agreement for GS 9-10, 7-8 and 6 PCa were 84-91%, 73-84%, 41-71%, (P=.023 and .001) and K=(0.72, 0.69, 0.23).
Conclusions:
CECT has good sensitivity for detecting GS ≥7 PCa with substantial agreement and a low false-positive rate.
