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Published on: November 30, 2013
MicroRNAs in renal cell carcinoma: a systematic review of clinical implications (Review)
Ming Li1, Ying Wang2, Yongsheng Song1
1Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
Abstract:
Despite recent advances in the understanding of the biology of renal cell carcinoma (RCC), successful surgical treatment and implementation of novel‑targeted therapies, the prognosis for RCC patients remains poor. Late presentation, tumor heterogeneity and in particular the lack of molecular biomarkers for early detection, classification and the surveillance of RCC treatments are major obstacles. The increasing knowledge regarding the functional role of microRNAs (miRNAs) in pathophysiological processes may provide an important link to the identification of suitable therapeutic targets and diagnostic/prognostic biomarkers for RCC. The aim of this review was to provide new insight into the function of miRNAs in the pathogenesis of RCC and to emphasize their potential as diagnostic and prognostic markers, as well as therapeutic targets.
Insights
MicroRNAs (miRNAs) show promise as biomarkers for early detection and prognosis in renal cell carcinoma (RCC). This review highlights their potential in diagnosing, predicting, and treating this challenging cancer.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Renal cell carcinoma (RCC) prognosis remains poor despite advances in treatment.
- Late presentation, tumor heterogeneity, and lack of molecular biomarkers hinder early detection and effective surveillance.
- MicroRNAs (miRNAs) play crucial roles in various pathophysiological processes.
Purpose of the Study:
- To review the function of miRNAs in RCC pathogenesis.
- To emphasize the potential of miRNAs as diagnostic and prognostic markers for RCC.
- To highlight miRNAs as potential therapeutic targets for RCC.
Main Methods:
- Literature review of studies on miRNA function in renal cell carcinoma.
- Analysis of current research on miRNA roles in RCC development and progression.
- Synthesis of findings regarding miRNA-based biomarkers and therapeutic strategies.
Main Results:
- miRNAs are implicated in the complex pathogenesis of RCC.
- Specific miRNAs demonstrate potential as biomarkers for early detection and classification.
- miRNAs offer possibilities for monitoring treatment response and predicting prognosis in RCC patients.
Conclusions:
- miRNAs represent a significant area for developing novel diagnostic and prognostic tools for RCC.
- Targeting miRNAs could lead to new therapeutic strategies for improving patient outcomes in RCC.
- Further research into miRNA mechanisms is essential for clinical translation in RCC management.
