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Androgens and human sexual behaviour.

J Bancroft, N E Skakkebaek

    Ciba Foundation Symposium
    |March 14, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Exogenous androgens, like testosterone, can improve sexual response in women when combined with counseling. However, effects are less consistent in women taking oral contraceptives or in hypogonadal males without specific interventions.

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    Area of Science:

    • Endocrinology
    • Human Sexual Response
    • Pharmacology

    Background:

    • Androgens are hypothesized to be crucial for sexual responsiveness in both human males and females.
    • Existing evidence supporting this hypothesis is limited and presents conflicting findings.
    • This study investigates the role of exogenous androgens in individuals with impaired sexual response.

    Purpose of the Study:

    • To evaluate the efficacy of exogenous androgens in treating sexual dysfunction.
    • To examine the effects of testosterone, androstenedione, and testosterone undecanoate in different patient groups.
    • To explore methodological challenges in assessing hormone therapy for sexual behavior.

    Main Methods:

    • Administered testosterone to women with impaired sexual response, combined with counseling.

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  • Provided androstenedione to sexually unresponsive women using oral contraceptives, without counseling.
  • Administered testosterone undecanoate to hypogonadal males and presented evaluation examples.

    • Main Results:

    • Testosterone combined with counseling significantly improved sexual response in women.
    • Androstenedione showed unusual beneficial effects in women taking oral contraceptives, especially without counseling.
    • Evaluation of androgen replacement in hypogonadal males yielded varied results, highlighting treatment complexities.

    Conclusions:

    • Exogenous androgens, particularly testosterone with counseling, show potential in treating female sexual dysfunction.
    • The effectiveness of androgens may be influenced by factors such as concurrent medication (oral contraceptives) and therapeutic support.
    • Further research is needed to address methodological issues in evaluating hormone effects on human sexual behavior.