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[Long-term outcomes of children treated with continuous renal replacement therapy]
S Almarza1, K Bialobrzeska1, M M Casellas1
1Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria, Hospital Gregorio Marañón, Madrid, Universidad Complutense de Madrid, Red de salud Maternoinfantil y del Desarrollo (Red SAMID), Madrid, España.
Insights
Most children who survive acute kidney injury and require continuous renal replacement therapy (CRRT) experience positive long-term outcomes and recover kidney function. This study highlights favorable medium-term results for pediatric CRRT patients.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Renal Replacement Therapy
Background:
- Acute kidney injury (AKI) is a critical condition in children.
- Continuous renal replacement therapy (CRRT) is a life-saving intervention for pediatric AKI.
- Long-term outcomes and kidney function post-CRRT require thorough investigation.
Purpose of the Study:
- To evaluate the long-term renal function and overall outcomes in children treated with CRRT for AKI.
- To identify factors influencing recovery and long-term kidney health in this vulnerable population.
Main Methods:
- Retrospective analysis of a prospective database.
- Inclusion of 128 pediatric patients requiring CRRT between 2006 and 2012.
- Assessment of outcomes for survivors at hospital discharge and during follow-up.
Main Results:
- Hospital survival rate was 54.4% (71 out of 128 patients).
- Of the 66 followed-up survivors, most demonstrated normal kidney function.
- Only one patient (1.6%) developed end-stage renal failure, with others showing temporary renal disturbances.
Conclusions:
- Children surviving AKI requiring CRRT generally have favorable medium-term outcomes.
- Low rates of mortality and significant recovery of kidney function are observed post-CRRT.
- CRRT is an effective treatment for pediatric AKI with good long-term renal prospects.
Introduction:
The objective of this study is to analyze long-term outcomes and kidney function in children requiring continuous renal replacement therapy (CRRT) after an acute kidney injury episode.
Patients And Methods:
A retrospective observational study was performed using a prospective database of 128 patients who required CRRT admitted to the pediatric intensive care unit between years 2006 and 2012. The subsequent outcomes were assessed in those surviving at hospital discharge.
Results:
Of the 128 children who required RRT in the pediatric intensive care unit, 71 survived at hospital discharge (54.4%), of whom 66 (92.9%) were followed up. Three patients had chronic renal failure prior to admission to the NICU. Of the 63 remaining patients, 6 had prolonged or relapses of renal function disturbances, but only one patient with atypical Hemolytic Uremic Syndrome developed end-stage renal failure. The rest had normal kidney function at the last check-up.
Conclusions:
Most of surviving children that required CRRT have a positive outcome later on, presenting low mortality rates and recovery of kidney function in the medium term.
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